Switzerland will win. Don't really see any strong contenders right now, so no idea what the top 3 will be.
The left side will be mostly ballads, unexpected non-hyped up mid-tempo and non-English entries. Most of the YASS QUEEEEN entries will end up on the right side, or not even make the final. Malta, Moldova and/or San Marino could make top 10.
Finland will make top 5. Italy somewhere in the middle, along with France. Russia will make top 10 for sure.
Iceland, Lithuania, Azerbaijan and Ukraine will not make top 10, or just barely so. Poland could make a shock left side. Australia will be in the middle along with them.
Netherlands will at least make top 15. Spain and Germany might make top 20. UK may very well be last again.
Denmark will qualify, possibly even make top 15. Norway will probably not qualify, and Sweden will get its worst result since 2010.
At least one really boring entry most seem to hate (Estonia, Austria etc.) will qualify, and several Eurofan favorites won't. Portugal will qualify but not much more. Ireland will not qualify, Macedonia might.
There will be some kind of tribute to, or pre-recorded appearance by the non-returning 2020 artists.
The stage will either be dark and empty (like 2018) or overloaded with video and light effects, making the overall impression cold and artificial. It will benefit intimate simple performances like Switzerland and Portugal, and really high-energy shows like Russia and Finland, but entries that need a warm atmosphere won't work well.
There hopefully won't be any serious technical problems like in 2018, but the performers will be a bit lost and confused since there is no audience. This will benefit those with a carefully planned staging, but those with a "straight up", more spontaneous performance will seem unengaged and fail to connect with viewers.
Pre-recorded vocals will be overused, leading to a backlash, both long term and directly against those entries that use it too much. At least two well-liked songs will get low jury points because of obvious non-live vocals.
The hosting will be pretty solid but boring, no language fumbles or Denmark-style awkwardness. The interval acts will be mostly pre-recorded, most not even on the same stage, and some kind of documentary clips may be shown in place of the later interval acts.